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In order to establish basic dat of SAMP6 as an animal model for osteoporosis, present study has been designed to concentrate on the various aspects of SAMP6 such as growth index, hematology, blood biochemistry, biochemical characteristics, and bone and cortical thickness. Investigation period was for 15 months (3 months to 18 months of age) and biological characteristics have been examined throughout the study period. The results were summarized as follows: Decreased body there were no significant differences in organ weights, generally those of male mice wwer greater than those of females, especially in liver, kidney and lung. According to the analysis of blood biochemistry and hematology, the number of leukocytes in male mice was greater than that of female mice. there was a decrease in bone thickness in both male and female mice starting around from 7 months of age. Peak cortical thickness index was noticed at 5months of age in both sexed. In femur, the highest Ca$^{2+}$ content for both sexed was noticed at 5 moths of age, whereas the highest P$^{3+}$ content was noted at the age of 5 and 7 months in male and femal mice, respectively. The contents of both elements were gradually decreased with age after peaks for both sexed. In summary, SAMP6 mice in KRICT colony show osteoporotic characteristics staring from 5 to 7 months of age, suggesting that at least 5 months of old animals should be used for studying the mechanism o9fm osteoporosis or screening anti-osteoporosis drugs. This study also suggests that the cortical index thickness, Ca$^{2+}$ and P$^{3+}$ contents, and alkaline phosphatase activities can be used as indexes for drug screening.
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